XL413 (hydrochloride)

Research use only, not for human use.

XL413 inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s = 118 and 140 nM, respectively) and reduces tumor growth in a COLO 205 mouse xenograft model.

XL413 is a potent inhibitor of Cdc7 (IC50 = 3.4 nM). It is >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively. XL413 inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s = 118 and 140 nM, respectively). It inhibits Cdc7-specific phosphorylation of mini-chromosome maintenance protein (MCM2) and induces cell cycle accumulation in the S and G2 phases in MDA-MB-231T and COLO 205 cells that overexpress Cdc7. In vivo, XL413 inhibits MCM2 phosphorylation (ED50 = <3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model when administered orally at doses of 10, 30, and 100 mg/kg.

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Others

Other Targets

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2062200-97-7

326.2

C14H12ClN3O2 ? HCl

>98% (HPLC)

H2O : 10 mg/mL (30.66 mM; Need ultrasonic)；DMSO : 3.4 mg/mL (10.42 mM; Need ultrasonic and warming)

O=C1N=C([C@@H]2CCCN2)NC3=C1OC4=C3C=C(Cl)C=C4.Cl

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(-20℃)

With Ice Pack

≥ 2 years